Structures of the death domain of the p75 neurotrophin receptor in complex with downstream effectors show how competitive protein-protein interactions orchestrate the hierarchical activation of downstream pathways in non-catalytic receptors.

The p75 neurotrophin receptor regulates when granule neuron progenitors exit the cell cycle in the developing cerebellum.

Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.

Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.

The hair follicle dermal condensate is populated via migration, and the cells exhibit early changes in cell shape and cell cycle status; Fgf20 primes these cellular and molecular events.

Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.

A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.

Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.

A novel neurotrophin signaling axis underpins a behavioral response to food scarcity.

Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.