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Dysmyelination of GABAergic hippocampal interneurons causes mislocalization of axonal ionic channels and disturbs their intrinsic physiological properties, suggesting that it may contribute to cognitive deficits observed in multiple sclerosis patients.

Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.

A new Cereblon-recruiting bifunctional tau ligand, QC-01-175, promotes aberrant tau degradation and rescue of stress vulnerability in human neuronal cell models of tauopathy.

Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.

Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.

An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.

BDNF axonal signaling regulates protein synthesis in neuronal cell bodies leading to dendritic arborization through dynein-dependent transport of signaling endosomes.

The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.

Changes in the interactome of the Rel family of transcription factors control adaptation to the environmental stress of hyperosmolarity and determine cell fate.

Spines with multiple excitatory contacts are potential sites for competition between thalamic and cortical axons, which is regulated by the astrocytes through the secreted synaptogenic protein hevin.