147 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Gamete expression of TALE class HD genes activates the diploid sporophyte program in Marchantia polymorpha

    Tom Dierschke et al.
    The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

    Lloyd Davis et al.
    A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
    1. Cell Biology
    2. Developmental Biology

    Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation

    Eléanor Simon et al.
    The glypicans Dally-like protein and Dally reveal functional non-redundancy of the Hedgehog co-receptors Boi and Ihog through independent interactions and specifically regulate cytoneme dynamics via the Ihog FNIII domain, thus setting long-range signaling.
    1. Microbiology and Infectious Disease

    Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

    Elisa De Crignis et al.
    Human liver organoids provide a patient-derived platform to interrogate host and viral mechanisms of HBV replication, perform anti-HBV and toxicity drug screens, and investigate the molecular determinants of related tumorigenesis.
    1. Plant Biology

    An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface

    Pooja Pandey et al.
    A pathogen effector mimics starvation-induced autophagy by subverting host endomembrane trafficking to stimulate biogenesis of autophagosomes around pathogen feeding sites, revealing how pathogens interlock distinct host compartments to facilitate infection.
    1. Chromosomes and Gene Expression

    A CTP-dependent gating mechanism enables ParB spreading on DNA

    Adam SB Jalal et al.
    A structural and biochemical approach shows that CTP binding and hydrolysis regulate nucleation, spreading, and recycling of a chromosome segregation protein ParB.
    1. Cell Biology

    CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels

    André Brás Gonçalves et al.
    Analysis of mutant cells combined with biochemical experiments reveals that CEP78 is recruited to the centrosome by CEP350 and regulates ciliogenesis and ciliary length control through CP110-dependent and CP110-independent mechanisms, respectively.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben C Tilly et al.
    Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey et al.
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Developmental Biology

    Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

    Kazuhide S Okuda et al.
    Live-imaging of a transgenic reporter of vascular Erk signalling in zebrafish reveals sequential signalling mechanisms during the initiation of regeneration in wounded blood vessels.

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