194 results found
    1. Neuroscience

    Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

    Emil Kind, Kit D Longden ... Mathias F Wernet
    The fly connectome reveals dedicated cell types for processing specific kinds of visual information such as color or skylight polarization.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta, Matthias Merkel ... Jeffrey D Amack
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.
    1. Biochemistry and Chemical Biology

    A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

    Jiale Du, Sandor Babik ... Eric Strieter
    The proteasomal deubiquitinase UCHL5/UCH37 uses a face distinct from the canonical ubiquitin binding site to engage K48-linked ubiquitin chains and catalyze chain debranching.
    1. Neuroscience

    Localized inhibition in the Drosophila mushroom body

    Hoger Amin, Anthi A Apostolopoulou ... Andrew C Lin
    A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.
    1. Immunology and Inflammation

    Ageing compromises mouse thymus function and remodels epithelial cell differentiation

    Jeanette Baran-Gale, Michael D Morgan ... Georg A Holländer
    Thymus ageing is characterised by both compositional and transcriptional shifts amongst epithelial cells that perturb their differentiation, contribute to organ atrophy and ultimately impair immune function.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

    Hayley Porter, Yang Li ... Suzana Hadjur
    STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.
    1. Computational and Systems Biology
    2. Developmental Biology

    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

    Huan Liu, Kaylia Duncan ... Robert A Cornell
    Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Plasmodium falciparum translational machinery condones polyadenosine repeats

    Slavica Pavlovic Djuranovic, Jessey Erath ... Sergej Djuranovic
    Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.
    1. Neuroscience

    Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

    Yanying Wu, Yosuke Funato ... Scott Waddell
    Regulated neuronal magnesium efflux is a critical element of normal and magnesium-enhanced memory.
    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai, Aurelie Bertin ... Patricia Bassereau
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.

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