5,224 results found
    1. Biochemistry and Chemical Biology

    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

    Nam Chu et al.
    NMR and biochemical analysis reveal new insights into how the critical protein kinase Akt is regulated by phosphorylation and is inhibited by an experimental therapeutic.
    1. Neuroscience

    Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH

    Jessica A Haley et al.
    The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Identification of distinct pH- and zeaxanthin-dependent quenching in LHCSR3 from Chlamydomonas reinhardtii

    Julianne M Troiano et al.
    Light-harvesting complex stress-related is a protein from photosynthetic green algae that prevents damage from sunlight via two distinct conformational processes, which protect against different timescales of solar fluctuations.
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast

    Sara N Mouton et al.
    In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.
    1. Structural Biology and Molecular Biophysics

    A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

    Daiane S Alves et al.
    The transmembrane domain of the EphA2 receptor has been transformed into a novel amphitropic peptide that binds to the EphA2 receptor and inhibits cell migration.
    1. Cell Biology
    2. Developmental Biology

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Cell Biology
    2. Cancer Biology

    Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

    Bree K Grillo-Hill et al.
    Increasing the internal pH of cells can induce dysplasia and enhance oncogene-increased cell growth, while decreasing the internal pH combined with oncogene expression leads to synthetic lethality.
    1. Microbiology and Infectious Disease

    Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

    Andrew Tze Fui Liew et al.
    Inside the acidic vacuole, expression, DNA binding and DNA binding affinity of the Salmonella regulator SsrB is stimulated by acid pH.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    pH- and sodium-induced changes in a sodium/proton antiporter

    Cristina Paulino, Werner Kühlbrandt
    Sodium ions but not protons induce defined helix movements in a sodium/proton antiporter and suggest a mechanism for Na + binding and transport.

Refine your results by:

Type
Research categories