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    1. Cell Biology
    2. Neuroscience

    Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

    Jiayao Zhang, Juan Li ... Weicai Liu
    miR-335-3p, which targets FOS and inhibits its activation of NFATC1 signaling, is an important regulator for osteoclast function and responsible for the psychological stress-induced osteoporosis.
    1. Immunology and Inflammation

    TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

    Nincy Debeuf, Sahine Lameire ... Bart N Lambrecht
    Rationalized selection of responsive TCR clones by single-cell analysis to aid in the generation of novel TCR transgenic animals.
    1. Neuroscience

    Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

    Diana M Karosas, Leslie Gonzales ... Kenneth S Henry
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

    Fan Sun, Pengrong Yan ... Zhaoxia Qu
    The novel PDLIM2 nanomedicine enhances chemoimmunotherapy for complete cure of lung cancer.
    1. Cell Biology

    Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

    Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana C Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Microbiology and Infectious Disease

    Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

    Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
    Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
    1. Neuroscience

    When abstract becomes concrete, naturalistic encoding of concepts in the brain

    Viktor Nikolaus Kewenig, Gabriella Vigliocco, Jeremy I Skipper
    A novel deep-learning-based computational method using object recognition to quantify visual context in naturalistic, multimodal stimuli demonstrates that a concept's perceived abstractness or concreteness dynamically depends on its visual context.
    1. Immunology and Inflammation

    Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

    Jasmine Rowell, Ching-In Lau ... Tessa Crompton
    The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage including 3’TRAV to 5’TRAJ.