285 results found
    1. Cell Biology
    2. Computational and Systems Biology

    The nucleus serves as the pacemaker for the cell cycle

    Oshri Afanzar, Garrison K Buss ... James E Ferrell Jr
    Just as the sinoatrial node acts as pacemaker for the heart, the nucleus acts as pacemaker for the Xenopus embryonic cell cycle.
    1. Cell Biology
    2. Developmental Biology

    Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish

    Kendall E Martin, Padmapriyadarshini Ravisankar ... Joshua S Waxman
    The transcription factor Nr2f1a represses ventricular and pacemaker cardiomyocyte identities within distinct regions of the zebrafish atrium.
    1. Neuroscience

    Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network

    Marc Chevalier, Natalia Toporikova ... Muriel Thoby-Brisson
    Pacemaker neurons are present in the preBötC circuitry of mouse embryos and their role in driving respiratory network activity changes during the critical period immediately before birth.
    1. Neuroscience

    Flexible utilization of spatial- and motor-based codes for the storage of visuo-spatial information

    Margaret M Henderson, Rosanne L Rademaker, John T Serences
    When human participants are able to plan responses in a visuo-spatial working memory task, sensory-like representations of remembered spatial position in early visual and parietal cortex adaptively trade off with motor-like representations of upcoming actions in sensorimotor cortex.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A single cell transcriptional roadmap of human pacemaker cell differentiation

    Alexandra Wiesinger, Jiuru Li ... Harsha D Devalla
    Diversification of human pacemaker subpopulations is directed by WNT and TGFβ signaling.
    1. Neuroscience

    Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia

    Alexis Bédécarrats, Laura Puygrenier ... Romuald Nargeot
    An atypical neuronal pacemaker mechanism triggers feeding motor pattern in Aplysia..
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker, Wesley A Leigh ... Kenton M Sanders
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Developmental Biology

    Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate

    Silja Barbara Burkhard, Jeroen Bakkers
    A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.
    1. Genetics and Genomics

    A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

    Yonghe Ding, Di Lang ... Xiaolei Xu
    Dnajb6 is identified as a novel sick sinus syndrome causative gene that exhibits a unique expression pattern within a subpopulation of sinus node pacemaker cells.

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