90 results found
    1. Epidemiology and Global Health

    Seasonal variation and etiologic inferences of childhood pneumonia and diarrhea mortality in India

    Daniel S Farrar et al.
    Nationally-representative verbal autopsies can be linked to seasonal patterns, clinical syndromes, and climate regions to describe novel insights regarding the microbiologic etiologies of childhood pneumonia and diarrhea in India.
    1. Cell Biology
    2. Human Biology and Medicine

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma et al.
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.
    1. Neuroscience

    Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

    Kevin M Goff, Ethan M Goldberg
    Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
    1. Microbiology and Infectious Disease

    Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

    Catherine R Armbruster et al.
    Subpopulations of polysaccharide producer and surface explorer cells play specialized roles in early Pseudomonas aeruginosa biofilm formation.
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs et al.
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Developmental Biology
    2. Neuroscience

    Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

    Elvira Diamantopoulou et al.
    Results of a zebrafish whole-animal chemical screen for compounds that can rescue ear and myelination defects in an adhesion GPCR (Adgrg6/Gpr126) mutant.
    1. Microbiology and Infectious Disease

    HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

    Pratibha C Koneru et al.
    Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant mutant virus indicating potential clinical benefits for combining these two classes of inhibitors.
    1. Structural Biology and Molecular Biophysics

    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

    Vasileios Kargas et al.
    Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.
  1. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez et al.
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.
    1. Epidemiology and Global Health

    Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa

    Sofonias Tessema et al.
    Combining parasite genetic and human mobility data can provide detailed information on local and cross-border connectivity, allowing programs to strengthen local and regional coordination for successful elimination of malaria.

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