96 results found
    1. Medicine
    2. Neuroscience

    tTARGIT AAVs mediate the sensitive and flexible manipulation of intersectional neuronal populations in mice

    Paul V Sabatini et al.
    tTARGIT AAVs offer a new approach to manipulate intersectional populations that produce selective and robust transgene expression and are easily modified.
    1. Neuroscience

    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Eiko Iwakoshi-Ukena et al.
    Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Neuroscience

    NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

    Chrysanthi Fergani et al.
    Kiss1 neurons and NKB-responsive neurons of the medial amygdala stimulate LH release in females through different (previously unknown) pathways which, in the case of NKB-responsive neurons, are kisspeptin-independent but estradiol-dependent.
    1. Cell Biology
    2. Neuroscience

    Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

    Santiago Vernia et al.
    Metabolic stress-induced activation of the JNK3 protein regulates excitatory transmission onto AgRP neurons to regulate food consumption.
    1. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos et al.
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
    1. Neuroscience

    POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

    Alexandre Caron et al.
    A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.
    1. Neuroscience

    Insulin regulates POMC neuronal plasticity to control glucose metabolism

    Garron T Dodd et al.
    Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.
    1. Neuroscience

    Cyclooxygenase-2 inhibition reduces stress-induced affective pathology

    Joyonna Carrie Gamble-George et al.
    Mechanistically distinct COX-2 inhibitors reduce stress-induced behavioral pathology via unique multimodal molecular mechanisms, and could be used to treat mood disorders.

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