442 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cell Biology

    Limitation of adipose tissue by the number of embryonic progenitor cells

    Kristina Hedbacker et al.
    The size of subcutaneous, but not visceral, fat depots is dependent on the number of embryonic adipocyte progenitors.
    1. Cell Biology

    A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

    Ka Man Carmen Chan et al.
    A viral fusogen drives cell-cell fusion by hijacking the actin machinery to directly couple actin assembly with a short fusogenic ectodomain.
    1. Ecology

    Rarity is a more reliable indicator of land-use impacts on soil invertebrate communities than other diversity metrics

    Andrew Dopheide et al.
    Rarity metrics reveal pervasive negative impacts of agricultural land use on soil invertebrate communities, whereas widely-used richness and diversity metrics underestimate the magnitude of these impacts.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

    Valerie PI Vidal et al.
    In the developing kidney, secreted molecules of the R-spondin family control progenitor cell proliferation and nephron formation by permitting WNT/β-catenin signalling.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez et al.
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

    Howard Choi et al.
    Metabolic labelling reveals complex proteome dynamics in tendon, with faster turnover of proteins in the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix.
  1. eLife Latest: Welcoming our newest editors

    Bringing expertise in all major areas of research at eLife, 111 researchers join our editorial board as nine Reviewing Editors move to the leadership team.

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