75 results found
    1. Cancer Biology

    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Carolina Marques et al.
    Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.
    1. Cancer Biology
    2. Cell Biology

    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

    Veethika Pandey et al.
    Blockage of CXCL10/CXCR3 signaling between murine pancreatic precancerous lesion cells and inflammatory macrophages generates a tumor-promoting microenvironment.
    1. Genetics and Genomics

    HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

    Jessica SY Ho et al.
    HNRNPM regulates exon inclusion and circularization events on transcripts of key homeostatic genes promoting cancer growth.
    1. Cancer Biology

    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

    Haritha Mathsyaraja et al.
    The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
    1. Cancer Biology

    Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

    Xin Zhou et al.
    Targeting aberrant CRTC-CREB activation blocks the growth of LKB1-inactivated lung cancer.
    1. Cancer Biology

    Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

    M Ines Pascoal Ramos et al.
    NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction, might be a powerful new strategy for cancer immunotherapy for collagen-rich immune-excluded tumors.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda et al.
    Tumor stiffness blocks T cell migration in tumors.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

    Shou Liu et al.
    ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

    Audrey M Hendley et al.
    Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.

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