Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4+ subset of embryonic origin located in the cortex and a Cx3cr1+ subset derived from adult hematopoietic stem cells residing in the medulla.
Christiane Pleuger, Dingding Ai ... Andreas Meinhardt
A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.
Omid Mashinchian, Xiaotong Hong ... C Florian Bentzinger
Cell encapsulation-based transcriptional profiling using myogenic progenitors reveals that long-range factors in the aged systemic environment induce a wide range of signaling pathways in a niche-independent manner.
Inducible fate-mapping analysis demonstrates that neither microglia, CD11c+ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.
Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
Scott M Anthony, Natalija Van Braeckel-Budimir ... John T Harty
Repeated antigen encounters alter the transcriptional state and function of lymph node-resident memory CD8+ T cells to mediate improved immunity against viral infection.