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    1. Immunology and Inflammation
    2. Neuroscience

    The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

    Xiao-Feng Zhao, Lucas D Huffman ... Roman J Giger
    Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
    1. Developmental Biology
    2. Immunology and Inflammation

    Thymic macrophages consist of two populations with distinct localization and origin

    Tyng-An Zhou, Hsuan-Po Hsu ... Ivan L Dzhagalov
    Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4+ subset of embryonic origin located in the cortex and a Cx3cr1+ subset derived from adult hematopoietic stem cells residing in the medulla.
    1. Immunology and Inflammation

    The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

    Christiane Pleuger, Dingding Ai ... Andreas Meinhardt
    A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.
    1. Computational and Systems Biology
    2. Ecology

    The LOTUS initiative for open knowledge management in natural products research

    Adriano Rutz, Maria Sorokina ... Pierre-Marie Allard
    The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.
    1. Cell Biology

    In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

    Omid Mashinchian, Xiaotong Hong ... C Florian Bentzinger
    Cell encapsulation-based transcriptional profiling using myogenic progenitors reveals that long-range factors in the aged systemic environment induce a wide range of signaling pathways in a niche-independent manner.
    1. Developmental Biology

    The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

    Yanyan Ding, Yuzhe Li ... Feng Liu
    A new zebrafish RBC aggregation model is developed to explore the dynamic process and the underlying regulatory mechanisms in blood clot formation.
    1. Immunology and Inflammation

    Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

    Xiaoting Wu, Takashi Saito ... Christiane Ruedl
    Inducible fate-mapping analysis demonstrates that neither microglia, CD11c+ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.
    1. Developmental Biology

    Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

    Cornelia Biehler, Katheryn E Rothenberg ... Patrick Laprise
    Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Immunology and Inflammation

    Protective function and durability of mouse lymph node-resident memory CD8+ T cells

    Scott M Anthony, Natalija Van Braeckel-Budimir ... John T Harty
    Repeated antigen encounters alter the transcriptional state and function of lymph node-resident memory CD8+ T cells to mediate improved immunity against viral infection.