3,585 results found
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells et al.
    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

    Bishnu P Paudel et al.
    Human telomerase unfolds and extends parallel G-quadruplexes using a unique mechanism involving its RNA template.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al.
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Evolutionary Biology

    Experimental evolution reveals hidden diversity in evolutionary pathways

    Peter A Lind et al.
    Genetic architecture governs the evolvability of adaptive paths providing a framework for evolutionary forecasting.
    1. Genetics and Genomics
    2. Neuroscience

    A scalable platform for the development of cell-type-specific viral drivers

    Sinisa Hrvatin et al.
    Highly paralleled functional evaluation of enhancer activity in single cells generates new cell-type-specific tools with broad medical and scientific applications.
    1. Developmental Biology
    2. Neuroscience

    Automated deep-phenotyping of the vertebrate brain

    Amin Allalou et al.
    Automated whole-brain analysis of gene expression at cellular resolution detects previously overlooked phenotypes in mutants and reveals parallels between the forebrains of zebrafish and mammals.
    1. Cell Biology

    Correction: No turnover in lens lipids for the entire human lifespan

    Jessica R Hughes et al.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.
    1. Evolutionary Biology

    Adaptation: Evolution of island lizards remains a mystery

    Kathryn D Kavanagh
    Lizards that live in the Greater Antilles exploit a large range of skeletal variations to adapt to similar habitats, in defiance of the theory of plasticity-led evolution.
    Insight
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