189 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G.-J Sterckx
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M Jore
    A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.
    1. Evolutionary Biology

    Discarded sequencing reads uncover natural variation in pest resistance in Thlaspi arvense

    Dario Galanti, Jun Hee Jung ... Oliver Bossdorf
    Aphid and mildew read counts leftover from the sequencing of greenhouse plants correlated with the environment of origin of the plants, and allowed the mapping of pathogen resistance genes.
    1. Ecology
    2. Evolutionary Biology

    Defensive symbionts provide high protection against natural enemies at low cost to hosts: a meta-analysis

    Cássia Siqueira Cesar, Eduardo SA Santos, Rodrigo Cogni
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

    Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Epidemiology and Global Health

    Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions

    Kathryn E Tiedje, Qi Zhan ... Karen P Day
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Cestode larvae excite host neuronal circuits via glutamatergic signaling

    Anja de Lange, Hayley Tomes ... Joseph V Raimondo
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Microbiology and Infectious Disease

    Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

    Nicholas J Hathaway, Isaac E Kim ... Jeffrey A Bailey
    Sequence analyses show a pfhrp3 deletion mechanism involves duplication of chromosome 11 segment, which is normally removed via negative selection, and specific conditions are needed for spread including low transmission.
    1. Microbiology and Infectious Disease

    Efficacy and mechanism of actions of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Epidemiology and Global Health

    From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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