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    1. Microbiology and Infectious Disease

    Tropical Diseases: Can CRISPR help in the fight against parasitic worms?

    Paul McVeigh, Aaron G Maule
    The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
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    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Gene Variation: The double-edged sword of evolution

    Etty Kruzel-Davila, Karl Skorecki
    Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease.
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    1. Microbiology and Infectious Disease

    Malaria: On a mission to block transmission

    Amanda Ross, Nicolas MB Brancucci
    The controlled infection of volunteers with Plasmodium falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
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    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Ecology

    The Natural History of Model Organisms: Peromyscus mice as a model for studying natural variation

    Nicole L Bedford, Hopi E Hoekstra
    The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.
    1. Evolutionary Biology

    The Natural History of Model Organisms: Insights into mammalian biology from the wild house mouse Mus musculus

    Megan Phifer-Rixey, Michael W Nachman
    Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.
    1. Ecology

    The Natural History of Model Organisms: The secret lives of Drosophila flies

    Therese Ann Markow
    After decades of intensive research, D. melanogaster and its relatives could provide important tools for investigating future biological questions about human health and environmental change, but only if we better understand their natural history.
    1. Microbiology and Infectious Disease

    Phylogeny: Are arthropods at the heart of virus evolution?

    Gytis Dudas, Darren J Obbard
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