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Genetic analyses in mice reveal a communication system between the knee joint and the developing bones that could be explored in studies addressing evolutionary changes in body proportions and in future therapies for growth disorders.

Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca²⁺]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.

A novel mechanism underlying the regulation of osteoblast morphology, adherence, and migration that has implications in bone remodeling, regeneration, and response to the pharmacological effects of PTH treatment.

Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.

A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.

In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.

Lipocalin-2 is a strong predictor of hunger scores, reflects an anti-obesity response that is deregulated in severely obese subjects, and exerts an anorexigenic function with a conserved interspecies mechanism.

Impaired bone microstructure and bone strength are prominent characteristics of rats with hemizygous E10-16del mutation in PLS3, and treatment with alendronate or teriparatide can improve bone mineral density and bone microstructure of this novel rat model with PLS3-related early-onset osteoporosis.

Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.

Age-stratified comparisons of gene expression in progeria patient fibroblasts reveals disruption of mesenchymal lineage pathways and points to a deficit in chondrogenic commitment in early development and a depletion of the mesenchymal lineage stem cell pool.