The inhibitory protein DEPTOR make two widely separated interactions with mTOR that are both necessary for its unique partial mTOR inhibition, and DEPTOR is a more potent inhibitor of mutation- or RHEB-activated mTORC1 than basal mTORC1.

Behavioral and synaptic investigations of long-term memory in Aplysia reveal differing roles for DNA methylation, protein synthesis during training and protein synthesis shortly after training with respect to memory consolidation and maintenance.

Partial response electromyography is a useful and reliable measure of action stopping in a stop signal task, supported by psychometric and meta-analytic evidence.

Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.

Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.

The sequence of neural and physiological processes underlying action-stopping has been delineated.

Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.

Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.

A new potent and selective CDK9 inhibitor induces the expression of the proto-oncogene MYC via a mechanism that depends on the bromodomain protein BRD4.

Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.