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The role of lysosomal Ca²⁺ flux associated with K⁺ efflux, a well-known event in inflammasome activation in metabolic inflammation and inflammasome activation, has been presented.

Across 63 large US cities, street tree communities are shaped by climate, clustered by species, and made more similar between cities due to the presence of introduced species.

How gene expression noise is regulated is critical for cell fate and tissue patterning.

Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.

To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.

Glutamine deprivation reprograms chondrocytes, attenuates inflammation, and such intervention may be protective against joint inflammation.

A new hominin species found in a South African cave is part of one of the most unusual hominin fossil assemblages on record.

Structural, biophysical, and functional analyses reveal that mutations in TREM2 trigger either misfolding or reduced binding to cell-surface glycosaminoglycans, which segregate with neurodegenerative disease link and highlight a functional surface linked to the pathogenesis of Alzheimer's disease.

The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.