10 results found
    1. Ecology

    Migration confers winter survival benefits in a partially migratory songbird

    Daniel Zúñiga et al.
    Testing of fitness-related benefits in migratory population of European blackbirds offers confirming predictions of theoretical models on the evolution and maintenance of migration.
    1. Cell Biology

    Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

    Adam L Hughes et al.
    A new mitochondrial protein degradation pathway selectively sorts and destroys a subset of the mitochondrial membrane proteome to protect mitochondria in times of stress.
    1. Ecology
    2. Neuroscience

    Select forelimb muscles have evolved superfast contractile speed to support acrobatic social displays

    Matthew J Fuxjager et al.
    In situ measurements of muscular twitch speed reveal one of the fastest vertebrate limb muscles on record, which evolved in association with extravagant courtship displays that include rapid limb movements.
    1. Computational and Systems Biology
    2. Neuroscience

    FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

    Zachary Daniel Burkett et al.
    Basal ganglia gene coexpression patterns shift across the sensorimotor critical period for vocal learning.
    1. Cell Biology

    Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

    Joseph D Mancias et al.
    NCOA4, the ferritin autophagy receptor, is regulated by HERC2 in an iron-dependent manner and is critical for red blood cell development.
    1. Ecology

    Oxygen isotopes suggest elevated thermometabolism within multiple Permo-Triassic therapsid clades

    Kévin Rey et al.
    Two therapsid clades, dicynodonts and cynodonts, independently acquired and developed an endotherm-like thermoregulation during the Late Permian period, that probably helped them to survive the major global climate and environmental fluctuations of the end-Permian.
    1. Developmental Biology and Stem Cells
    2. Evolutionary Biology

    Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

    Siu-Shan Mak et al.
    Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.
    1. Evolutionary Biology
    2. Plant Biology

    Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes

    Glen Wheeler et al.
    Genomic evidence suggests that L-gulonolactone oxidase-the terminal enzyme in vitamin C synthesis, which has been repeatedly lost throughout animal evolution-was lost in plants and other photosynthetic eukaryotes following plastid acquisition.
    1. Evolutionary Biology
    2. Cancer Biology

    Evolutionary dynamics of cancer in response to targeted combination therapy

    Ivana Bozic et al.
    A study that models the evolution of drug resistance in tumors reveals that drugs are more effective when given in combination than sequentially, and that cure is much more likely when the drugs target different pathways.
    1. Genetics and Genomics
    2. Cancer Biology

    Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Young Seok Ju et al.
    Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.

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