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    1. Cancer Biology
    2. Computational and Systems Biology

    Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

    Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten
    A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
    1. Ecology
    2. Evolutionary Biology

    Complex plumages spur rapid color diversification in kingfishers (Aves: Alcedinidae)

    Chad M Eliason, Jenna M McCullough ... Michael J Andersen
    Treating color patterns in a geometric morphometrics framework reveals rapid rates of color evolution that are explained by a combination of intrinsic organismal features (color variation among patches) and geography within a cosmopolitan radiation of birds.
    1. Ecology
    2. Evolutionary Biology

    Earliest evidence for fruit consumption and potential seed dispersal by birds

    Han Hu, Yan Wang ... Roger BJ Benson
    Fruit consumption of Jeholornis was evidenced and indicates seed dispersal was present from early in avian radiation.
    1. Evolutionary Biology
    2. Neuroscience

    Proposing a neural framework for the evolution of elaborate courtship displays

    Ryan W Schwark, Matthew J Fuxjager, Marc F Schmidt
    The midbrain periaqueductal grey is a conserved mediator of elaborate courtship behavior in a range of vertebrate taxa, likely shaping how this behavior diversifies across the tree of life.
    1. Ecology
    2. Epidemiology and Global Health

    Both consumptive and non-consumptive effects of predators impact mosquito populations and have implications for disease transmission

    Marie C Russell, Catherine M Herzog ... Andrew C McCall
    While predators can clearly reduce mosquito populations by consumption, they can also have non-consumptive effects on mosquito body size and oviposition behavior, and these effects on vector traits can influence infectious disease dynamics.
    1. Ecology
    2. Neuroscience
    Silhouette of a zebra finch on a blue background.

    The Natural History of Model Organisms: Neurogenomic insights into the behavioral and vocal development of the zebra finch

    Mark E Hauber, Matthew IM Louder, Simon C Griffith
    The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

    Carter J Barger, Linda Chee ... Adam R Karpf
    FOXM1 is co-expressed with its bidirectional gene partner RHNO1, and the two genes promote DNA repair, cell growth and survival, and chemotherapy resistance in ovarian cancer.
    1. Biochemistry and Chemical Biology
    2. Ecology

    The energy savings-oxidative cost trade-off for migratory birds during endurance flight

    Scott McWilliams, Barbara Pierce ... Ulf Bauchinger
    Migratory birds with fuel stores composed of more omega-6 fats saved energy during long-duration flights, but this short-term energy saving came at the long-term cost of higher oxidative damage.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transient intracellular acidification regulates the core transcriptional heat shock response

    Catherine G Triandafillou, Christopher D Katanski ... D Allan Drummond
    When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.
    1. Ecology
    2. Evolutionary Biology

    Alcids ‘fly’ at efficient Strouhal numbers in both air and water but vary stroke velocity and angle

    Anthony B Lapsansky, Daniel Zatz, Bret W Tobalske
    Four species of seabird produce efficient propulsive wakes while flying in the air and while swimming underwater suggesting that selection has optimized these species for locomotion in remarkably different fluids.