1,360 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The discriminatory power of the T cell receptor

    Johannes Pettmann et al.
    The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.
    1. Microbiology and Infectious Disease

    Calcium signaling through a transient receptor channel is important for Toxoplasma gondii growth

    Karla Marie Márquez-Nogueras et al.
    A transient receptor channel in Toxoplasma gondii that conducts calcium represents the first molecular element that initiates upstream calcium signals that activate parasite pathogenic pathways.
    1. Neuroscience

    Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

    Laifu Li et al.
    Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
    1. Computational and Systems Biology
    2. Neuroscience

    Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

    Jack Goffinet et al.
    Modern machine learning methods offer new techniques for analyzing complex vocal behavior like ultrasonic mouse calls and birdsong.
    1. Biochemistry and Chemical Biology

    The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

    Neha Puri et al.
    Structure-guided biochemistry defines how the coupling between nucleic acid substrate binding and ATPase activity is used by a molecular switch to load ring-shaped motor proteins onto single-stranded DNA.
    1. Cell Biology
    2. Neuroscience

    High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

    Haining Zhong et al.
    A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu et al.
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Cell Biology

    Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

    Stephanie E Crilly et al.
    A GPCR activated by the same agonist engages different conformational biosensors at different subcellular locations, suggesting that location-based conformations drive spatial encoding of signaling.
    1. Developmental Biology
    2. Neuroscience

    Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

    Shu-Min Chou et al.
    Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.

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