556 results found
    1. Neuroscience

    Multi-neuron intracellular recording in vivo via interacting autopatching robots

    Suhasa B Kodandaramaiah et al.
    A robot capable of automatically obtaining blind whole cell patch clamp recordings from multiple neurons simultaneously guides four interacting electrodes in a coordinated fashion, avoiding mechanical coupling in the brain.
    1. Neuroscience

    Endocytosis: Recycling at synapses

    Owen P Gross, Henrique von Gersdorff
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
  1. Point of View: Basic research at the epicenter of an epidemic

    William R Bishai
    William R Bishai, director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), argues that the best place to carry out research into a disease is in its midst.
  2. Point of View: Tell me a story

    Joshua R Sanes
    Many authors start with the figures when writing a paper, but it is easier to tell a good story if you start with the Introduction and Results, and leave the figures to later.
    1. Biochemistry and Chemical Biology

    Cytokines: Revealing the secrets of secretion

    Antony Galione, Lianne C Davis
    An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-protein detection in crowded molecular environments in cryo-EM images

    J Peter Rickgauer et al.
    High-resolution template matching makes small, densely embedded proteins detectable.

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