563 results found
    1. Neuroscience

    Competition between parallel sensorimotor learning systems

    Scott T Albert, Jihoon Jang ... Reza Shadmehr
    When a common error drives parallel implicit and explicit learning systems, increases in the explicit response will suppress implicit adaptation.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva, Adrian Jacobo ... A J Hudspeth
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Developmental Biology

    Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland

    Qiang Lan, Ewelina Trela ... Marja L Mikkola
    Live imaging, transcriptional profiling and mouse models demonstrated that the mesenchyme controls the growth pace but not the mode of branching of the mammary epithelium and unveiled a unique function for Igf1/Igfr1 in embryonic development mammary gland.
    1. Neuroscience

    Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo

    Carolin Gehr, Jeremie Sibille, Jens Kremkow
    Excitatory and inhibitory neurons in the mouse superior colliculus receive comparably strong inputs from retinal ganglion cells, in contrast to the thalamocortical system.
    1. Neuroscience

    Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

    Rashmi Sarnaik, Indira M Raman
    Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
    1. Evolutionary Biology
    2. Neuroscience

    Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human

    Petra Wahle, Eric Sobierajski ... Gundela Meyer
    Archived histological material from tracing studies, immunohistochemistry, and Golgi impregnations allowed to discover a so far unrecognized structural difference, potentially of functional importance, between neocortical pyramidal neurons of rodent, carnivore, and ungulate as compared to monkey and man.
    1. Structural Biology and Molecular Biophysics

    Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

    SeCheol Oh, Fabrizio Marinelli ... Richard K Hite
    The energetic costs of ion dehydration in the pore of human TMEM175 determine its ion selectivity.
    1. Developmental Biology
    2. Plant Biology

    Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

    Dan Zhang, Roxane P Spiegelhalder ... Michael T Raissig
    The formation of stomatal 'helper cells' (=subsidiary cells) in grasses requires two opposing polarity domains with diverse roles in establishing division asymmetry.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Computational and Systems Biology
    2. Neuroscience

    A stochastic neuronal model predicts random search behaviors at multiple spatial scales in C. elegans

    William M Roberts, Steven B Augustine ... Shawn R Lockery
    A stochastic model of locomotory control in C. elegans based on an extensive new set of tracking data can explain and predict effects of ablations and mutations on behavior.

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