1,340 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide et al.
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Biochemistry and Chemical Biology

    Structure-guided microbial targeting of antistaphylococcal prodrugs

    Justin J Miller et al.
    Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.
    1. Developmental Biology
    2. Genetics and Genomics

    Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

    Yukiko Tando et al.
    Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
    1. Microbiology and Infectious Disease

    KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

    Rajnish Kumar Singh et al.
    KSHV nullifies hypoxic restriction of DNA replication.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu et al.
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat et al.
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Ecology

    An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

    Lei Guo et al.
    The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.
    1. Ecology
    2. Evolutionary Biology

    Living with relatives offsets the harm caused by pathogens in natural populations

    Hanna M Bensch et al.
    Experiments show that pathogens spread more easily among relatives causing increased mortality, but such costs are cancelled out by the benefits of living with kin when pathogens are rare.

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