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SIRT1 and SIRT3-mediated immunometabolic shift governs intracellular Salmonella proliferation both in vitro and in vivo and dissemination in mice, thereby influencing the infection outcomes.

A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.

Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.

Enterococci faecium encodes unique peptidoglycan composition and remodeling activity that activates host immunity.

The first lethal Junín virus challenge model in immunocompetent mice provides insight into New World mammarenavirus pathogenesis and will serve as a model for the development of much-needed therapeutic interventions.

Innate lymphoid cells type 1 suffice to induce hallmarks of alopecia areata phenotype in organ-cultured human scalp hair follicles ex vivo and in human scalp skin xenotransplants in vivo, suggesting that these cells play a role in early AA pathogenesis.

Ablation of the G-protein-coupled receptor C3aR1 specifically on macrophages or Kupffer cells does not alter the course of metabolic dysfunction-associated steatotic liver disease in a dietary mouse model.

Understanding communication mechanisms between unicellular parasites is crucial in the development of novel therapies, as they rely on diverse modes of communication (like extracellular vesicle release, cytoneme, and filopodia formation) to regulate their behavior and survival.

Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.

Disruption of quality control pathways that function at distinct steps to mitigate errors in translation evoke similar cellular responses and pathologies.