197 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands

    Altaira D Dearborn et al.
    Cryo-electron microscopy and genetics show how Staphylococcus aureus pathogenicity island 1 hijacks the assembly pathway of a helper phage for its own propagation.
    1. Microbiology and Infectious Disease

    Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

    Janine Bowring et al.
    Structural and genetic analyses reveal the highly evolved and unprecedented biological strategy used by SaPIs to spread in nature.
    1. Microbiology and Infectious Disease

    Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

    Eleanor Gaunt et al.
    Mutants of influenza A virus with increased CpG dinucleotide frequencies show restricted replication and reduced or absent pathogenicity, and powerful host innate and adaptive responses to infection that confer immunity to re-infection.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnaporthe oryzae

    Xinyu Liu et al.
    A phosphorylation circuitry balancing among kinase, transcription factor, transcription repressor, and phosphatase in response against host immunity during M. oryzae–rice interaction.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Glycan-based shaping of the microbiota during primate evolution

    Sumnima Singh et al.
    Ggta1 deletion in mice shapes and reduces the microbiota pathogenicity and probably contributed to the natural selection of GGTA1 loss-of-function mutations in the ancestral primates that gave rise to humans.
    1. Microbiology and Infectious Disease

    Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

    Alex C Stabell et al.
    An analysis of innate immunity reveals why dengue viruses do not reach high titers in primate laboratory models, even though they emerged through zoonotic transmission from primate reservoirs.
    1. Microbiology and Infectious Disease

    An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence

    Jeanyoung Jo et al.
    During growth in biofilms and host infection, the opportunistic pathogen Pseudomonas aeruginosa employs respiratory heterocomplexes that support extracellular electron shuttling and pathogenicity.
    1. Cell Biology
    2. Neuroscience

    Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

    Sean L Johnson et al.
    Pathogenesis in Spinocerebellar Ataxia Type 3 is enhanced by the heat-shock protein family member, Hsc70-4, uncovering new mechanisms of toxicity for this disease and suggesting pleiotropic roles for chaperones.
    1. Immunology and Inflammation

    A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

    Fei Tang et al.
    A novel population of hematopoietic cells unmasked by mTORC1 inactivation reveals a new mechanism of innate immune tolerance and a new consequence of defective hematopoiesis.
    1. Ecology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay et al.
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.

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