Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.

The entire biosynthetic pathway for the diterpenoid forskolin in Coleus forskohlii has been reconstituted in yeast.

Feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.

Molecular structure of mitochondrial complex I from Drosophila melanogaster reveals a structural element not seen in other organisms to date that may regulate the transition between an off-pathway resting state and the active state of the complex.

A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.

Metformin extends C. elegans lifespan through lysosome-dependent coordination of TORC1 and AMPK pathways.

Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.

Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.

The complement pathway can contribute to corneal sensation loss and nerve damage during ocular surface inflammation.

Elucidating the 1-naphthylamine degradation pathway in Pseudomonas sp. strain JS3066 and analyzing the catalytic mechanism of the 1-naphthylamine glutamine synthetase deepens the understanding of microbial degradation of polycyclic aromatic amines.