Activity in the pedunculopontine tegmental nucleus reflects the choices and outcomes of previous trials in a decision making task, and affects upcoming choices.
Daniel J Galtieri, Chad M Estep ... D James Surmeier
Pedunculopontine neurons can evoke burst spiking in substantia nigra dopaminergic neurons without engaging a subtype of glutamate receptor previously thought to be necessary for this spiking mode.
A brain-wide mapping of the direct inputs to striatal cholinergic and parvalbumin interneurons reveals connectivity differences and implies their distinct roles in regulating striatal function.
The most comprehensive neuroanatomical atlas on the expression of three glycoprotein hormone receptors, namely, TSHRs, LHCGRs, and FSHRs, was mapped using RNAscope, a technology that allows the detection of mRNA at single-transcript level.
Romain Durand-de Cuttoli, Sarah Mondoloni ... Alexandre Mourot
In vivo deconstruction of reward-related behaviors with circuit and pharmacological specificity using designer, light-controllable nicotinic acetylcholine receptors.
Conditional deletion of the DYT1 dystonia protein torsinA causes selective cell autonomous neurodegeneration of striatal and brainstem cholinergic neurons, and severe motor behavioral abnormalities.
Neural circuit monitoring and manipulation reveal that neurons of the rostral intralaminar nuclei of the thalamus projecting to the dorsal striatum activate at movement initiation and reward to reinforce actions.