134 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

    Ali H Alghamdi et al.
    Study of TbAQP2 adaptations and substrate interactions shows how this aquaglyceroporin enables cellular entry of large antimicrobial agents in Trypanosoma brucei.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

    Damien Lemoine et al.
    A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the eukaryotic retinal importer ABCA4

    Fangyu Liu et al.
    The structures of ABCA4 in two conformations provide a framework to understand its transport mechanism.
    1. Evolutionary Biology
    2. Neuroscience

    A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

    Christian Damsgaard et al.
    A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

    Ksenya Cohen Katsenelson et al.
    Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

    Adriana E Golding et al.
    Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of signaling specificity between GIRK channels and GPCRs

    Kouki K Touhara, Roderick MacKinnon
    A single kinetic step in the G protein activation cycle determines whether a G protein-coupled receptor activates G protein-gated K+ channels or not.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergy between RecBCD subunits is essential for efficient DNA unwinding

    Rani Zananiri et al.
    A new optical tweezers assay sheds light on the mechanism of cooperation and force generation by the subunits of RecBCD, critical for the repair of double strand breaks in bacteria.

Refine your results by:

Type
Research categories