2,373 results found
    1. Immunology and Inflammation

    Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

    Marisa Stebegg et al.
    Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
    1. Immunology and Inflammation

    Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

    Robert A Benson et al.
    Temporal availability of antigen presentation by dendritic cells influences the differentiation of follicular helper T (Tfh) cells, which enhances germinal centre responses and induces protective immunity.
    1. Immunology and Inflammation

    Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

    Jialong Yang et al.
    Genetic ablation of Raptor and Rictor in mice revealed critical roles of mTORC1 and mTORC2 in T follicular helper cell differentiation and germinal center responses.
    1. Cell Biology

    Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

    Shekhar Srivastava et al.
    The mammalian potassium channel KCa3.1, which is important for T- and B-cell activation, is inhibited by cytoplasmic copper, mediated by a histidine residue (His358) that is phosphorylated to activate the channel.
    1. Immunology and Inflammation

    CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

    Michelle A Linterman et al.
    The co-stimulatory molecule CD28 is required after T cell priming for helper T cell polarization in response to an infection.
    1. Immunology and Inflammation

    The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

    Heather D Marshall et al.
    Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra et al.
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Cell Biology
    2. Immunology and Inflammation

    Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

    Roybel R Ramiscal et al.
    The ubiquitin ligase ROQUIN cross-talks with cellular metabolic signals to generate protective T cell-dependent antibody responses.
    1. Cell Biology
    2. Human Biology and Medicine

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al.
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.

Refine your results by:

Type
Research categories