7,318 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

    Mary F Fontana, Erica Ollmann Saphire, Marion Pepper
    Flow cytometric analysis of antigen-specific B and T cell responses to heterologous immunization reveals intact dendritic cell function, but selective defects in germinal center formation, in mice with concurrent malaria.
  1. Meta-Research: Weak evidence of country- and institution-related status bias in the peer review of abstracts

    Mathias Wullum Nielsen, Christine Friis Baker ... Jens Peter Andersen
    A preregistered survey experiment spanning six disciplines has found weak evidence of bias in favour of authors from high-status countries and institutions.
    1. Medicine

    Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

    Chelsea Hepler, Mengle Shao ... Rana K Gupta
    Genetic inactivation of the transcription factor, Zfp423, in visceral white adipocyte precursors leads to the formation of thermogenic adipocytes in visceral fat depots and improves insulin sensitivity in obese mice.
    1. Cell Biology

    Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

    Chelsea Hepler, Bo Shan ... Rana K Gupta
    Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
    1. Structural Biology and Molecular Biophysics

    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

    Lan Wang, Alexander Myasnikov ... Peter Walter
    Msp1 recruits substrates at the open seam of the spiral oligomer and extracts them with functionally adapted elements.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

    Jonas Klinkhammer, Daniel Schnepf ... Peter Staeheli
    Interferon-λ plays a decisive and previously underestimated role in limiting the spread of respiratory viruses from the nasal cavity to the lungs and it efficiently restricts virus transmission from infected individuals to naïve contacts.
    1. Neuroscience

    Humans treat unreliable filled-in percepts as more real than veridical ones

    Benedikt V Ehinger, Katja Häusser ... Peter König
    In a forced decision between two identical percepts, subjects preferentially rely on inferred internally generated over veridically seen percepts.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis

    Abhishek Aich, Cong Wang ... Peter Rehling
    Biochemical analyses show that mitochondrial COX16 assists in the process of copper insertion into COX2 and reveal a second COX16 function in linking assembly routes of the redox center-containing COX1 and COX2 subunits.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    COVID-19 cluster size and transmission rates in schools from crowdsourced case reports

    Paul Tupper, Shraddha Pai ... Caroline Colijn
    Fitting a simple model of COVID-19 transmission to crowdsourced case report data allowed the estimation of mean cluster size and transmission rates in Canadian schools, as well as determining which interventions are most likely to limit transmission.
    1. Neuroscience

    ChatGPT identifies gender disparities in scientific peer review

    Jeroen PH Verharen
    Generative artificial intelligence, such as OpenAI’s ChatGPT, can be used to analyze scientific texts with specialized constructions, including peer review reports.

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