Michael JD Daniels, Lucas Lefevre ... Barry W McColl
Cst7, a gene coding for protein cystatin F, is expressed by microglia in neurodegenerative disease models and mediates sex-dependent effects on microglial endolysosomal function and disease pathology.
Solène N Lefebvre, Antoine Taly ... Pierre-Jean Corringer
A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
An individual-based model framework of sub-exponentially growing replicator systems suggests that parabolic dynamics could have been able to maintain genetic diversity and circumvent the error threshold problem during early evolution.
Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.
The neuromodulator acetylcholine contributes to state-dependent modulation of motor vigor and variability by direct action on songbird premotor cortex, bypassing basal ganglia circuitry.
Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
