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    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

    Yansheng Li, Mingkai Xu ... Chenggang Zhang
    By fusing influenza viral conserved epitopes and a superantigen fragment, we constructed a recombinant protein that might be a candidate universal broad-spectrum vaccine for the prevention and treatment of multiple influenza viruses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females

    Snigdha Misra, Mariana F Wolfner
    A seminal protein from a mating-male can bind sperm previously stored in his mate, providing direct benefits to the sperm from the prior male that mated with her.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

    Richard Panayiotou, Francesc Miralles ... Richard Treisman
    G-actin binding controls the susceptibility of MRTF-A to phosphorylation, which works in concert with multiple NES elements to regulate MRTF-A subcellular localisation and activity.
    1. Developmental Biology
    2. Evolutionary Biology

    CRISPR knockouts reveal an endogenous role for ancient neuropeptides in regulating developmental timing in a sea anemone

    Nagayasu Nakanishi, Mark Q Martindale
    Analysis of the endogenous function of deeply conserved neuropeptides in sea anemones sheds light on a primitive role of nervous systems in modulating developmental timing.
    1. Biochemistry and Chemical Biology

    SETD3 protein is the actin-specific histidine N-methyltransferase

    Sebastian Kwiatkowski, Agnieszka K Seliga ... Jakub Drozak
    Histone-lysine N-methyltransferase SETD3 (NP_115609.2) was identified as the actin-specific histidine N-methyltransferase, an enzyme catalyzing the extremely well-conserved methylation of H73 in β-actin.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl, Zeynep Hein ... Sebastian Springer
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

    Curtis McMurtrey, Thomas Trolle ... William Hildebrand
    T. gondii infection alters how peptide ligands are presented to the immune system by inducing a previously unreported structural change in Human Leukocyte Antigens (HLAs).
    1. Biochemistry and Chemical Biology

    Ribozyme activity modulates the physical properties of RNA–peptide coacervates

    Kristian Kyle Le Vay, Elia Salibi ... Hannes Mutschler
    The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

    Karmel A Allison, Eniko Sajti ... Christopher K Glass
    Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.
    1. Microbiology and Infectious Disease

    Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

    Bikash Shakya, Saurabh D Patel ... Elizabeth S Egan
    The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.