550 results found
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Developmental Biology
    2. Neuroscience

    Robo2 regulates synaptic oxytocin content by affecting actin dynamics

    Savani Anbalagan et al.
    Real-time monitoring of oxytocin-loaded vesicles and synaptic actin dynamics in zebrafish reveal that Slit3-Robo2-Cdc42 signalling maintains steady-state levels of mature oxytocin neuropeptide readily primed to be secreted upon physiological demand.
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook et al.
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Developmental Biology

    The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

    Chengdong Liu et al.
    Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca2+]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.
    1. Developmental Biology

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

    Erik C Hansen et al.
    Uracil/adenine base pairs in HIV-1 DNA are attacked by the uracil base excision repair machinery in macrophages, which leads to HIV restriction and viral genome diversification by transcription-associated mutagenesis.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Non-classical amine recognition evolved in a large clade of olfactory receptors

    Qian Li et al.
    Fish trace amine-associated receptors evolved a novel structural motif that enables the detection of chemically diverse amine odors in a non-canonical 'inverted' orientation.
    1. Neuroscience

    Hunger neurons drive feeding through a sustained, positive reinforcement signal

    Yiming Chen et al.
    Hunger neurons promote feeding by triggering a long-lasting potentiation of the rewarding properties of food.

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