426 results found
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

    Julia Santiago et al.
    A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

    Lisa Seidel et al.
    Agonist and antagonist peptides of the corticotropin-releasing factor receptor type 1 adopt different folds and stabilize distinct conformations of the receptor transmembrane domain, which involves tilting of helices VI and VII around conserved glycine hinges.
    1. Plant Biology

    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway

    Nils Stührwohldt et al.
    Step-wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory pathway is required for formation and secretion of the bioactive peptides.
    1. Neuroscience

    High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

    Jian Qiu et al.
    Kisspeptin neurons in the hypothalamus release peptide and amino acid neurotransmitters that work together to coordinate the activity of gonadotropin-releasing hormone neurons and subsequent release of reproductive hormones.
    1. Developmental Biology

    The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

    Christian SM Helker et al.
    Elabela-Apelin receptor signaling is a novel pathway that regulates angioblast migration, instead of the proposed migration regulation through Vascular endothelial growth factor.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient origins of arthropod moulting pathway components

    André Luiz de Oliveira et al.
    Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
    1. Cell Biology

    Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

    Maria Daniela Garcia-Castillo et al.
    Non-native synthetic short-chain glycosphingolipids fused to GLP-1 enable intestinal absorption with high bioavailability in vivo.
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal et al.
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators

    Wilson Mena et al.
    The response of the peptidergic neurons that control a stereotyped behavior depends on the actions of a triggering neuropeptide, downstream neuropeptides and GABA inhibitory influences.

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