1,549 results found
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Structural Biology and Molecular Biophysics

    Structural basis for SARM1 inhibition and activation under energetic stress

    Michael Sporny et al.
    Cryo-EM shows that the NADase activity of SARM1 is allosterically inhibited by physiological concentrations of NAD+ that stabilizes an auto-inhibited conformation of SARM1, explaining how NAD+ depletion may inflict neurodegeneration.
    1. Cell Biology

    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

    Chang Zhang et al.
    BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang et al.
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Neuroscience

    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

    Shaun S Sanders et al.
    ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.
    1. Medicine

    Lipocalin-2 is an anorexigenic signal in primates

    Peristera-Ioanna Petropoulou et al.
    Lipocalin-2 is a strong predictor of hunger scores, reflects an anti-obesity response that is deregulated in severely obese subjects, and exerts an anorexigenic function with a conserved interspecies mechanism.
    1. Genetics and Genomics
    2. Neuroscience

    High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

    Qiaochu Li et al.
    Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.
    1. Biochemistry and Chemical Biology

    Talin-activated vinculin interacts with branched actin networks to initiate bundles

    Rajaa Boujemaa-Paterski et al.
    At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.
    1. Neuroscience

    Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers

    Tobias Lieblein et al.
    Monitoring the formation of two distinct arrangements in early amyloid-ß aggregation by mass spectrometry and ion mobility allows determination of the effect of potential drug candidates.

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