1,740 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

    Curtis McMurtrey et al.
    T. gondii infection alters how peptide ligands are presented to the immune system by inducing a previously unreported structural change in Human Leukocyte Antigens (HLAs).
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

    Lisa Seidel et al.
    Agonist and antagonist peptides of the corticotropin-releasing factor receptor type 1 adopt different folds and stabilize distinct conformations of the receptor transmembrane domain, which involves tilting of helices VI and VII around conserved glycine hinges.
    1. Plant Biology

    The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate

    Xingyun Qi et al.
    A binary cell fate decision to be or not to be stomata is regulated by multiple peptide ligands, each triggering a unique subcellular dynamics of their shared receptor.
    1. Immunology and Inflammation

    T cell immunodominance is dictated by the positively selecting self-peptide

    Wan-Lin Lo et al.
    The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

    Jerome C Nwachukwu et al.
    Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes et al.
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

    Jinsai Shang et al.
    Synthetic PPARγ ligands push and cobind with natural endogenous ligands, instead of compete and displace, which synergistically affects the structure and function of PPARγ.
    1. Neuroscience

    Luqin-like RYamide peptides regulate food-evoked responses in C. elegans

    Hayao Ohno et al.
    Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
    1. Immunology and Inflammation

    Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

    Marco Künzli et al.
    T cell receptor signal strength correlates positively with Th1 generation during acute infection but negatively during chronic infection.
    1. Evolutionary Biology
    2. Neuroscience

    Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

    Luis Alfonso Yañez-Guerra et al.
    Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.

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