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    1. Plant Biology

    UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

    Hannes Vanhaeren et al.
    By inactivating DA1, DAR1 and DAR2 through deubiquitination, UBP12 and UBP13 regulate leaf growth, cell area and endoreduplication.
    1. Plant Biology

    The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors

    Byoung Il Je et al.
    The maize CLAVATA receptor, FEA2, functions in the perception of two different ligands, and remarkably that signaling from these different inputs is differentiated by the receptor interacting with two different downstream components.
    1. Neuroscience

    Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers

    Tobias Lieblein et al.
    Monitoring the formation of two distinct arrangements in early amyloid-ß aggregation by mass spectrometry and ion mobility allows determination of the effect of potential drug candidates.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma et al.
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Timothy F Miles et al.
    Numerous chemokine variants bearing no sequence resemblance elicit similar signaling behavior from the viral GPCR US28, suggesting a mechanism for receptor activation that accommodates extensive ligand degeneracy.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

    Dominik Witzigmann et al.
    The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.
    1. Structural Biology and Molecular Biophysics

    A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

    Daiane S Alves et al.
    The transmembrane domain of the EphA2 receptor has been transformed into a novel amphitropic peptide that binds to the EphA2 receptor and inhibits cell migration.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

    Julia Santiago et al.
    A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
    1. Cancer Biology

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph et al.
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
    1. Biochemistry and Chemical Biology

    Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter

    Joanne L Parker et al.
    Two thermodynamically distinct transport mechanisms operating within the same binding site explains the remarkable promiscuity of POT family transporters towards peptide and drug ligands.