The catalytic activity of a Drosophila neprilysin is critical to proper insulin expression and food intake by regulating homeostasis of distinct signaling peptides.

A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.

The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in order to ensure proper stomatal development on the plant epidermis.

Two cell-penetrating peptides that inhibit Ras-ERK signalling and a potent clinically relevant MEK inhibitor block cocaine conditioned place preference and accelerate extinction of cocaine self-administration upon a single administration in mice.

The maize CLAVATA receptor, FEA2, functions in the perception of two different ligands, and remarkably that signaling from these different inputs is differentiated by the receptor interacting with two different downstream components.

Oxytocin, a peptide linked to the processing of socially meaningful stimuli, modulates excitatory synaptic transmission in dopaminergic neurons of ventral tegmental area via retrograde endocannabinoid signaling, acting as a pathway-specific temporal filter for synaptic inputs.

A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.

The same genes and signalling pathways control the formation of skin appendages in both fish and land animals.