864 results found
    1. Biochemistry and Chemical Biology

    Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter

    Joanne L Parker et al.
    Two thermodynamically distinct transport mechanisms operating within the same binding site explains the remarkable promiscuity of POT family transporters towards peptide and drug ligands.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malodour precursor transport in the human axilla

    Gurdeep S Minhas et al.
    Discovery of the structural basis for recognition and uptake of a human precursor for body odour production reveals an important role for bacterial peptide transport and novel routes to prevent its production in humans.
    1. Biochemistry and Chemical Biology

    Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

    Silvia C Bobeica et al.
    Structural and biochemical characterization of the protease domain of an ABC transporter demonstrates the basis for recognition of substrate leader peptides.
    1. Immunology and Inflammation

    Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

    Brogan Yarzabek et al.
    Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
    1. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe et al.
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters

    Cheng-Hsun Ho, Wolf B Frommer
    Peptide and nitrate transporters have been converted into fluorescent reporters of transport activity and have been used to measure various transport properties including the dual affinity of the nitrate transceptor
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structure of the transporter associated with antigen processing trapped by herpes simplex virus

    Michael L Oldham et al.
    Herpes simplex virus evades the immune response by inhibiting the TAP transporter with a peptide inhibitor ICP47 that has an extensive interface at the peptide translocation cavity and locks the transporter in an inactive state.
    1. Human Biology and Medicine
    2. Neuroscience

    Tissue Engineering: Building a better blood-brain barrier

    Courtney Lane-Donovan, Joachim Herz
    A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.
    Insight
    Available as:
    • HTML
    • PDF

Refine your results by:

Type
Research categories