85 results found
    1. Computational and Systems Biology

    Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator

    Michael Jahn, Nick Crang ... Elton Paul Hudson
    Proteomics and metabolic modeling revealed that the 'knallgas' bacterium Cupriavidus necator utilizes only a fraction of its proteome and keeps large enzyme reserves as an adaption to variable environments.
    1. Microbiology and Infectious Disease

    Robust manipulation of the behavior of Drosophila melanogaster by a fungal pathogen in the laboratory

    Carolyn Elya, Tin Ching Lok ... Michael Eisen
    A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel, Nicholas I Cejda ... Phillip A Newmark
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Biochemistry and Chemical Biology

    On the role of nucleotides and lipids in the polymerization of the actin homolog MreB from a Gram-positive bacterium

    Wei Mao, Lars D Renner ... Rut Carballido-Lopez
    First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

    Roee Ben Nissan, Eliya Milshtein ... Ron Milo
    Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO2.
    1. Chromosomes and Gene Expression

    A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae

    Lucas M Walker, James RJ Haycocks ... David C Grainger
    Overlapping DNA-binding specificity allows global transcription factors to cooperatively bind the same DNA sites and integrate two signals in the control of gene expression.
    1. Computational and Systems Biology

    Structural assembly of the bacterial essential interactome

    Jordi Gómez Borrego, Marc Torrent Burgas
    A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.
    1. Microbiology and Infectious Disease

    Hosts manipulate lifestyle switch and pathogenicity heterogeneity of opportunistic pathogens in the single-cell resolution

    Ziguang Wang, Shuai Li ... Wei Liu
    The host acts as an important factor to control the phenotypic heterogeneity of individual symbionts.
    1. Microbiology and Infectious Disease

    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

    Nora C Pyenson, Luciano A Marraffini
    Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.
    1. Microbiology and Infectious Disease

    Phage resistance profiling identifies new genes required for biogenesis and modification of the corynebacterial cell envelope

    Amelia C McKitterick, Thomas G Bernhardt
    Using bacteriophages as probes, new genes involved in cell surface construction were identified in a class of bacteria that includes important pathogens like Mycobacterium tuberculosis.

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