108 results found
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim et al.
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Microbiology and Infectious Disease

    PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM

    Sabrina Wamp et al.
    Analysis of suppressor mutants led to the identification of a novel signalling pathway that regulates peptidoglycan biosynthesis in Gram-positive bacteria.
    1. Microbiology and Infectious Disease

    Global phenotypic profiling identifies a conserved actinobacterial cofactor for a bifunctional PBP-type cell wall synthase

    Joel W Sher et al.
    A broadly useful phenotypic profiling dataset was generated and used to identify a cofactor required for a polar cell wall synthase in Corynebacterium glutamicum that is conserved throughout the Actinobacteria.
    1. Microbiology and Infectious Disease

    Bacteria: Driving polar growth

    Neeraj Dhar
    Profiling the phenotype of 200,000 mutants revealed a new cofactor that may help a group of rod-shaped bacteria elongate and grow.
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    1. Microbiology and Infectious Disease

    Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite

    Stephanie G Hays, Kimberley D Seed
    Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity

    Gurmeet Kaur et al.
    Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel et al.
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Microbiology and Infectious Disease

    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

    Nora C Pyenson, Luciano A Marraffini
    Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

    Gizem Özbaykal et al.
    For initiation of cell-wall insertion, the cross-linking enzyme PBP2 stably binds to a component of the cell envelope that is different from MreB filaments.
    1. Microbiology and Infectious Disease

    Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

    Allison Hillary Williams et al.
    Lytic transglycosylase enhances the activity of its protein partner, and its catalytic domain can be targeted to disrupt cell-wall integrity, protein partner function, and bacterial survival (Neisseria meningitidis) in hosts.

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