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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Tuberculosis: Breaking down walls

    Moagi Tube Shaku, Bavesh Davandra Kana
    A better understanding of the mechanisms underpinning the growth of mycobacteria could help identify targets for new antibiotics.
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    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic et al.
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.
    1. Microbiology and Infectious Disease

    An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics

    Prahathees J Eswara et al.
    GpsB in Staphylococcus aureus directly regulates the central cell division protein FtsZ, a different function from that assigned for GpsB in other closely related organisms.
    1. Microbiology and Infectious Disease

    Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

    Saurabh Mishra et al.
    Intrinsic tolerance of Mycobacterium tuberculosis toward the world's most successful antibacterials, β-lactams, is dependent on cytoplasmic redox potential and an intracellular redox-sensor WhiB4.
    1. Microbiology and Infectious Disease

    A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis

    Josué Flores-Kim et al.
    Penicillin induces bacterial cell lysis by altering cell surface polymer biogenesis to cause the misactivation of a cell wall degrading enzyme.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The molecular architecture of engulfment during Bacillus subtilis sporulation

    Kanika Khanna et al.
    In situ cryo-electron tomography unveils the molecular sociology of a developing sporangium in Bacillus subtilis, revealing critical information about cell wall remodeling and membrane migration in bacteria.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain et al.
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Microbiology and Infectious Disease

    Molecular coordination of Staphylococcus aureus cell division

    Victoria A Lund et al.
    Morphological constraints dictate division mode in the human pathogen Staphylococcus aureus.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Bacterial Proliferation: Off the wall

    Dennis Claessen, Gilles P van Wezel
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