9 results found
    1. Microbiology and Infectious Disease

    A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

    Sunil Kumar Dogga et al.
    An aspartyl protease is essential for the lytic cycle of Toxoplasma gondii and is involved in the maturation of proteins critical for invasion and egress, and it can be targeted selectively with an ethylamine scaffold based peptidomimetic inhibitor.
    1. Biochemistry and Chemical Biology

    Science Forum: Donated chemical probes for open science

    Susanne Müller et al.
    A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

    Paola Favuzza et al.
    The structure of the promising malaria blood-stage vaccine candidate antigen PfCyRPA and the characterization of a protective epitope are facilitating research on its essential role in parasite invasion, and will guide future epitope-focused vaccine design.
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber et al.
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Biochemistry and Chemical Biology

    Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

    Patrick J Nygren et al.
    Flexibility is a defining feature of AKAP kinase-phosphatase assemblies and points toward a mechanism whereby combinatorial recruitment of binding partners tailors the overall conformation of the macromolecular assembly, allowing customized physiological roles.
    1. Neuroscience

    Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

    Stefanie Giera et al.
    A combined approach of unbiased proteomics, biochemistry, genetics, and transgenic animal models reveals that GPR56/ADGRG1 regulates myelin formation and repair by interacting with its microglial-derived ligand transglutaminase 2.
    1. Cancer Biology

    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

    Song Liu et al.
    Coregulators mediate selective interactions between DNA-bound androgen receptor and other transcription factors, which control distinct prostate cancer biology, suggesting disruption of critical interactions in these complexes as a novel therapeutic strategy.
    1. Cancer Biology

    Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

    Laura Cato et al.
    Targeting the activation of the androgen receptor N-terminal domain by the cochaperone Bag-1L provides a new approach for inhibiting androgen receptor function to treat prostate cancer.

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