Browse the search results

Page 3 of 5
    1. Biochemistry and Chemical Biology

    Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

    Kyle Mangano, Tanja Florin ... Nora Vázquez-Laslop
    Inhibition of bacterial protein synthesis by an antimicrobial peptide apidaecin triggers translation arrest at the stop codons, ribosome queuing and pervasive stop codon readthrough.
    1. Cell Biology
    2. Computational and Systems Biology

    Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

    Andrew D Bailey, Jason Talkish ... Manuel Ares
    A method enabling identification of more than 100 RNA modifications in single ribosomal RNA molecules uncovers new classes of modified ribosomes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu, Kyota Yasuda ... Stavroula Mili
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Biochemistry and Chemical Biology

    The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

    Mikael Holm, Chandra Sekhar Mandava ... Suparna Sanyal
    The antibiotic viomycin induces errors during initial codon selection by the ribosome by locking the monitoring bases in their active conformation.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger, Jarod A Rollins ... Markus Schosserer
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

    Chen Bao, Sarah Loerch ... Dmitri N Ermolenko
    By sterically hindering tRNA binding and inhibiting translation elongation, mRNA stem-loops can modulate gene expression.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

    André Heuer, Emma Thomson ... Roland Beckmann
    Near atomic resolution of late 40S ribosomal subunit assembly by cryo-EM reveals immature rRNA active sites stabilized by biogenesis factors.
    1. Biochemistry and Chemical Biology

    Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs

    Chi-Ning Chuang, Hou-Cheng Liu ... Ting-Fang Wang
    Noncanonical usage of stop codons in ciliates expands structurally flexible Q-rich domains and coevolves with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1

    Jesper Pallesen, Yaser Hashem ... Joachim Frank
    Cryo-electron microscopy has been used to provide a structural interpretation of the complete action cycle of release factor 3 during translation termination, which includes a coordinated sequence of interactions with a class-I release factor and the ribosome.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    Eriko Matsuura-Suzuki, Tadahiro Shimazu ... Shintaro Iwasaki
    METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.