262 results found
    1. Neuroscience

    Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

    Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan ... Turgay Dalkara
    Pericytes surrounding capillaries in the retina contain α-smooth muscle actin, demonstrating that pericytes have the necessary molecular machinery to change capillary diameter during neurovascular coupling.
    1. Cell Biology

    Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

    Fergus M O'Farrell, Svetlana Mastitskaya ... David Attwell
    Lack of reperfusion of cardiac capillaries, when an upstream artery is unblocked following heart attack, reflects contractile pericytes constricting capillaries and preventing blood flow, implying that cardiac pericytes are a therapeutic target for treating cardiac ischaemia.
    1. Cell Biology
    2. Neuroscience

    Pericytes control vascular stability and auditory spiral ganglion neuron survival

    Yunpei Zhang, Lingling Neng ... Xiaorui Shi
    Pericytes in the adult ear are critical for vascular stability and spiral ganglion neuron health.
    1. Developmental Biology

    Pericytes are progenitors for coronary artery smooth muscle

    Katharina S Volz, Andrew H Jacobs ... Kristy Red-Horse
    Progenitor cells for the muscle layer around the coronary arteries have been identified revealing a key step in how the embryo forms these important blood vessels.
    1. Cell Biology
    2. Medicine

    Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

    Felipe Freitas, David Attwell
    Renal capillary pericytes are a novel therapeutic target for reducing sustained reduction in renal blood flow ('no-reflow') after kidney ischaemia.
    1. Computational and Systems Biology
    2. Medicine

    Single-cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction

    Seo-Gyeong Bae, Guo Nan Yin ... Jihwan Park
    Single-cell RNA sequencing analysis of diabetic mouse cavernous tissue revealed that LBH is a novel pericyte marker and may interact with Crystallin Alpha B and Vimentin to promote neurovascular regeneration.
    1. Neuroscience

    Distinct signatures of calcium activity in brain mural cells

    Chaim Glück, Kim David Ferrari ... Bruno Weber
    Increases of extracellular potassium silence capillary pericyte calcium signaling, suggesting a participation of capillary pericytes in the potassium-mediated neurovascular communication.
    1. Medicine

    A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

    Runze Yang, Tianhao Xu ... Weili Fu
    Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
    1. Plant Biology

    Phloem unloading in Arabidopsis roots is convective and regulated by the phloem-pole pericycle

    Timothy J Ross-Elliott, Kaare H Jensen ... Karl J Oparka
    A study of solute and macromolecule trafficking in plants reveals a previously undescribed route for carbon distribution in growing root tissues.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu, Yiyun Wang ... Aaron Watkins James
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.

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