49 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Neuroscience

    Correction of amblyopia in cats and mice after the critical period

    Ming-fai Fong et al.
    Visual impairment caused by monocular deprivation early in life can be reversed rapidly at older ages by temporarily blocking all activity in the non-deprived eye.
    1. Cell Biology
    2. Developmental Biology

    The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

    Xiaoling Li et al.
    A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.
    1. Developmental Biology
    2. Evolutionary Biology

    Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

    Astrid Deryckere et al.
    Neurogenic progenitor cells surrounding the eye placode generate neurons that migrate over long distances to the developing octopus brain.
    1. Neuroscience

    Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

    Sayali V Gore et al.
    Chronic dysregulation of matrix-metalloproteinase 9, which is associated with some neurodevelopmental disorders, leads to local hyperconnectivity in the developing brain, resulting in altered sensory processing and increased seizure susceptibility.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Injection with Toxoplasma gondii protein affects neuron health and survival

    Oscar A Mendez et al.
    Multi-level profiling of Toxoplasma gondii-injected neurons identifies brain regions and neuron subtype predilections as well as the effect of Toxoplasma interactions on neuron physiology and health.
    1. Neuroscience

    Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

    Sharon R Stevens et al.
    Analysis of AnkyrinR conditional knockout mice shows that AnkyrinR regulates PV+ fast-spiking interneurons by organizing and maintaining perineuronal nets and through the membrane clustering of Kv3.1b K+ channels.
    1. Neuroscience

    Uncovering a ‘sensitive window’ of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings

    Jasmien Orije et al.
    Despite the structural sexual dimorphism in the song control system, both male and female starlings experience similar seasonal neuroplasticity in multisensory systems and cerebellum during the photosensitive phase, which acts as a sensitive window of plasticity.
    1. Cell Biology

    Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent

    Helen Hertenstein et al.
    Detailed analysis of transporter expression and glucose uptake rates shows that carbohydrate import at the blood–brain barrier is adapted via TGF-βsignaling-dependent transcriptional regulation of carbohydrate transporters to protect the brain form effects of nutrient shortage.
    1. Developmental Biology
    2. Neuroscience

    Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

    Cassandra B Klune et al.
    An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.

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