501 results found
    1. Structural Biology and Molecular Biophysics

    STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

    Vivek Krishnan, Sher Ali ... Scott Earley
    STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca2+entry.
    1. Structural Biology and Molecular Biophysics

    Arteries: STIMulating blood pressure

    Tessa AC Garrud, Jonathan H Jaggar
    The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

    Qi Wang, Erik M Vogan ... John Kuriyan
    A key B-cell tyrosine kinase that adopts an autoinhibited conformation, and can be activated by either membrane recruitment or soluble inositol hexakisphosphates in solution.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

    Chad Paul Grabner, Tobias Moser
    The mouse rod photoreceptor ribbon creates a large number of releasable vesicles with uniform release kinetics.
    1. Neuroscience

    Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain

    Romain Cardis, Sandro Lecci ... Anita Lüthi
    Neuropathic pain preserves mouse sleep in architecture and characteristic spectral bands but perturbs arousability in ways reminiscent of insomnia disorders, in which hyperarousal and hyperalertness to environmental stimuli are prevalent.
    1. Structural Biology and Molecular Biophysics

    Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

    Piotr Kolata, Rouslan G Efremov
    The dynamic structure of respiratory complex I from mesophilic bacterium is revealed and demonstrates existence of uncoupled conformations in the bacterial complex.
    1. Cell Biology
    2. Genetics and Genomics

    Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

    Peter S Johnstone, Maite Ogueta ... Deniz Top
    Locally activatable bioluminescence (LABL) is a genetically encoded reporter that allows real time, in vivo measurement of distinct clocks in different cells and tissues in Drosophila.
    1. Neuroscience

    A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields

    Luca Cocchi, Martin V Sale ... Jason B Mattingley
    The selective effect of local inhibition on diffuse patterns of brain connectivity can be accounted for by an intrinsic hierarchical ordering of cortical timescales.
    1. Neuroscience

    Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice

    Sebastian H Zahler, David E Taylor ... Evan H Feinberg
    Mouse gaze shifts are unexpectedly flexible.
    1. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson, Andrea E Cocoran ... Susan M Dymecki
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.

Refine your results by:

Type
Research categories