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    1. Neuroscience

    Nutritional state-dependent modulation of insulin-producing cells in Drosophila

    Rituja S Bisen, Fathima Mukthar Iqbal ... Jan M Ache
    An in vivo electrophysiology approach identifies an incretin-like effect in Drosophila insulin-producing cells, highlighting key circuit dynamics which govern glucose homeostasis via conserved mechanisms.
    1. Neuroscience

    Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons

    Darya Task, Chun-Chieh Lin ... Christopher J Potter
    Olfactory neurons of insects, once thought to express only a single type of olfactory receptor, exhibit widespread co-expression of receptors from multiple chemosensory gene families.
    1. Neuroscience

    Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

    Jing Xu, Timothy Ma ... John Krakauer
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning

    Hélène Vitet, Julie Bruyère ... Frédéric Saudou
    Studies in mice and neurons reveal how modulation of the axonal transport of synaptic vesicles via huntingtin phosphorylation influences the number of vesicles accumulating at the synapse, subsequent glutamate release, and behavior in mice.
    1. Neuroscience

    Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons

    Filipe Nascimento, Matthew James Broadhead ... Gareth Brian Miles
    The pairing of chemogenetic and electrophysiological approaches reveals mechanisms by which cholinergic synapses modulate the final motor output of the nervous system.
    1. Developmental Biology
    2. Neuroscience

    Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

    Einav Wircer, Janna Blechman ... Gil Levkowitz
    Experiments in zebrafish reveal a new role for a critical hypothalamic transcription factor, orthopedia, in controlling developmental neuropeptide balance in a discrete oxytocin-producing neuronal circuit whose disrupted development affects social behavior.
    1. Developmental Biology

    Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

    Marketa Kaucka, Julian Petersen ... Igor Adameyko
    The brain and olfactory epithelium play a key role in pattering chondrogenic areas in the developing face, which is partly based on the release of SHH from neurosensory structures into the facial mesenchyme.
    1. Genetics and Genomics
    2. Medicine

    Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS

    Elisabet Stener-Victorin, Gustaw Eriksson ... Anna Benrick
    Elevated levels of ectopic fat and a decreased number of oxidative insulin-sensitive type I muscle fibers in skeletal muscle could lead to insulin resistance in women with polycystic ovary syndrome.
    1. Cell Biology
    2. Neuroscience

    The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

    Katalin Skrapits, Miklós Sárvári ... Erik Hrabovszky
    Neuroanatomical studies reveal presence and cholinergic phenotype of 150,000-200,000 extrahypothalamic gonadotropin-releasing hormone neurons in human basal ganglia and basal forebrain, and RNA-sequencing detects gonadotropin-releasing hormone receptor-1 expression in cholinergic interneurons but not in spiny projection neurons of the human putamen.
    1. Neuroscience

    High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

    Daniel Haenelt, Robert Trampel ... Nikolaus Weiskopf
    In vivo quantitative magnetic resonance imaging at ultra-high magnetic field reveals systematic differences of relaxation parameters (R1) within the human secondary visual cortex at the level of the thin-thick-pale stripes system, which points toward higher cortical myelination of pale stripes.