1,587 results found
    1. Medicine

    Cardiovascular adaptation to hypoxia and the role of peripheral resistance

    Andrew S Cowburn et al.
    Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.
    1. Cell Biology

    CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

    Adi Drori et al.
    The hepatic endocannabinoid/CB1R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Cell Biology

    Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

    Ramesh Chennupati et al.
    Genetic mouse models identify a critical mechanism of myogenic vasoconstriction and reveal the in vivo function of myogenic autoregulation in protecting from organ overperfusion and in maintaining vascular resistance.
    1. Immunology and Inflammation
    2. Medicine

    Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

    Daniela Fraccarollo et al.
    Immature CD10neg neutrophils and CD14+HLA-DRneg/low monocytes inducing proinflammatory and adaptive immune responses emerge in patients with large acute myocardial infarction.
    1. Cell Biology
    2. Developmental Biology

    Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

    Yan Xiong et al.
    Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
    1. Neuroscience

    A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

    Lihong Zhan et al.
    A hidden population of microglial progenitors with distinct transcriptomic signatures are among homeostatic microglia in adult mouse brain.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
    1. Cell Biology

    Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

    Kerstin Klinkert et al.
    Experiments reveal mechanisms through which Caenorhabditis elegans zygotes depleted of Aurora A or lacking centrosomes spontaneously establish two posterior PAR-2 domains, one at each pole, in a curvature-dependent manner.
    1. Neuroscience

    When complex neuronal structures may not matter

    Adriane G Otopalik et al.
    Animal-to-animal variability in neuronal geometry may be compensated for by compact electrotonic structure.

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